Carbidopa-Levodopa (Sinemet)

Sinemet is used to treat Parkinson’s disease.

  • Classifications: Autonomic Nervous System Agent; Anticholinergic; Antiparkinsonism Agent
  • Available in Capsule & Tablet forms

Geriatric

  • Elderly patients may have increase chance of side effects during treatment due to high sensitivity.

Contraindications

  • Narrow-angle glaucoma
  • Pregnancy (category C)

Caution in

  • Kidney disease
  • Diabetes mellitus
  • Chronic lung disease

Side effects

  • Urine, saliva, and sweat become darker in color than usual.
  • May cause a bitter taste, or a burning sensation of the tongue

Interactions – MAOI, Tricyclic antidepressants, Haloperidol

Nursing Implications

  • Observe for therapeutic effects and report adverse reactions promptly.
  • Monitor vital signs & rhythm, particularly during period of dosage adjustment.

Patient teaching

  • Teach to make position changes slowly, particularly from sitting to upright position.

Reference: Roach’s Introductory Clinical Pharmacology. 

Rophem Nursing 🙂

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